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3.1.2 Exenatide As the first GLP-1R agonist approved for T2DM, EX is a new class of compound and a synthetic product of exendin-4, which is a compound naturally derived from the Gila monster and has multiple hypoglycemic mechanisms: inhibiting of glucagon release from cells, slowing of gastric emptying, decreasing appetite and increasing glucose-dependent insulin secretion ( Lipotoxicity induced by saturated free fatty acids plays a vital role in renal injury in obese patients ( There is little research on the weight loss effect of EX on simple obesity patients, and more clinical trials are conducted on patients with T2DM
Sanofi 7.1.7
The primary GLP-1 action in rodents' bone is to promote bone formation by stimulating osteoblasts through the regulation of runt-related transcription factor 2 (RUNX2), alkaline phosphatase, collagen type 1, and osteocalcin [55]
The pairing is based on separate pathways and community research interest
This makes it especially beneficial for athletes and those involved in rigorous physical activities
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