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Molecules , 25(3), 609.
It is handed between proteins in a thermodynamic hierarchy, and the relevant partners named in the GHK literature include serum albumin, which has a dedicated high-affinity N-terminal site, ceruloplasmin as the dominant circulating copper protein, metallothioneins as high-capacity intracellular sinks, and cuproenzymes that require the metal to function
However, when given subcutaneously, GHK-Cu bypasses this barrier and the peptide gets into circulation systemically at the desired dose
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