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One clinical trial compared the weight loss outcomes for semaglutide vs

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GLP-1s are highly effective at controlling blood sugar and slowing down gastric processes, but they are also highly effective (so to speak) at bringing on side effects like constipation, nausea, and abdominal pain that, if untreated, will impact adherence and, in turn, short and long term results

SURMOUNT-1 and TRIUMPH-4 enrolled different populations (TRIUMPH-4 included only people with knee osteoarthritis), and direct head-to-head trials comparing retatrutide and tirzepatide havent been completed

Potential Side Effects Because they work on the digestive system, both medications share similar potential side effects