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42 In another study in beagles in a research setting, measures of oxidative stress (malondialdehyde or MDA) were higher in older dogs, along with apparently compensatory increases in both glutathione peroxidase and SOD activities

The lapse went largely unnoticed until it was recently highlighted by Derek Lowe in Science, where he described it as an eyebrow-raising moment for a company with so much at stake

More recently, the SUMMIT trial demonstrated that tirzepatide reduced the composite risk of cardiovascular death or worsening heart failure by 38% (HR = 0.62, 95% CI: 0.410.95) in patients with heart failure with preserved ejection fraction (HFpEF) and a BMI 30 kg/m 2 , 32% of whom also had type 2 diabetes

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