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P-21 (P021) a novel neurogenic peptide compound
Orforglipron Name: Orforglipron Manufacturer: Eli Lilly Current stage: Expected to submit for regulatory approval by the end of 2025 Takeaway: Less effective than injectables for mean weight loss, but a daily pill could suit some patients better
Patients with isolated LCHAD deficiency or generalized MTP deficiency share most of the clinical signs and symptoms with other lcFAODs, but are the only lcFAOD in which patients can develop peripheral neuropathy and pigmentary retinopathy [23,24,25, 62, 126,127,128]
However, discontinuing the medication entirely often leads to weight regain because GLP-1s address physiological drivers of hunger and metabolism that persist even after weight loss
Meanwhile, Vitamin E may help relieve symptoms like hot flashes, vaginal dryness, and mood change
