Gastrointestinal adverse events were reported in 62% of the group taking semaglutide, compared to 42% in the placebo group.[ref] Bigger picture of GLP-1 in the rise of obesity: Several recent studies shed light on how environmental factors may be causing a decrease in GLP-1 levels
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10.1152/japplphysiol.00958.2013 47 SheN.ShiY.FengY.MaL.YuanY.ZhangY.et al
And with that, in this particular patient, her lymphedema went from mild to not so mild anymore
Why results vary wildly: Dose tolerance: If you cant tolerate higher doses due to side effects, your results will be more modest Adherence: Stopping early or inconsistently using the medication significantly reduces results Protein intake: Under-eating protein accelerates muscle loss Activity level: Sedentary women lose more muscle and less fat Stress and sleep: Both affect results independently of the medication Starting weight: People with more to lose typically see larger absolute numbers Side Effects Women Over 40 Should Watch For (And How to Manage Them) Gastrointestinal issues (very common): Nausea, constipation, diarrhea, vomiting, acid reflux
