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Diagnosis should be confirmed by the gold standard, scintigraphy

It arises due to a combination of genetic and lifestyle factors that contribute to defective production of insulin from pancreatic beta cells, and/or resistance to its uptake by insulin receptors located in peripheral and central tissues in the body

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For many individuals, this means reducing frequency from twice or three times weekly to once weekly, or adjusting doses downward while monitoring for any reduction in therapeutic benefits

Pills are also easier to manufacture than injectable pens, which could help avoid the frustrating supply problems that slowed earlier GLP-1 launches