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Its directly driving increased energy expenditure and fat oxidation in a way that GLP-1 alone NEVER delivers
The glucagon receptor (only retatrutide activates this)
Though Tresiba has a lower hypoglycemia rate than some other insulins due to its flat action profile, the risk is always present
That said, DEXA is certainly imperfect in splicing the details of this body composition change as adipose tissue includes plenty of lean mass. Additionally, the placebo group lost more lean mass (-1.83kg) than fat mass (1.37kg), which shows potential error. Nadolsky pointed out that rapid weight loss, in general, will reduce resting metabolic rate to some degree
Living most of my adult life feeling uncomfortable for being bigger, this was the very first time in my life I'd felt self-conscious for having a smaller body
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