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As an investigational triple-agonist, fully understanding its long-term cardiovascular, gastrointestinal, and pancreatic safety profile is essential before it can transition from a research setting to routine clinical practice. Dr
In the HepG2 fatty liver cell model, hypoxia-inducible factor-2alpha (HIF-2)/PPAR pathway was found to be essential for Lira to inhibit liver lipid synthesis and reduce lipid-induced hepatic steatosis [57]
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