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These modifications reduce binding to IGF binding proteins substantially, extending the half-life while maintaining receptor activation

The difference in absorption speed between sites is relatively modest for long-acting GLP-1 formulations

This provides the convenience of nasal administration for the systemically-acting peptide while maintaining local concentration of BPC-157 where targeted healing is desired

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This design ensures spatial separation of the GLP-1 N-terminus from the albumin moiety, preserving receptor-binding capacity and maintaining full biological activity