10.1086/345375 56 DeclercqW.Vanden BergheT.VandenabeeleP
Higher predisposition to adverse effects Additionally, people who had previously used gastrointestinal medications -- which may indicate they are more vulnerable to the common adverse gastrointestinal side-effects reported by GLP1-RA users, such as nausea, vomiting, diarrhea -- were 9% more likely to discontinue semaglutide within the first year
"Ozempic is indicated for people with a BMI over 27 if they have weight-related complications like high blood pressure, or a BMI over 30 if they are otherwise healthy," says Jennifer Brown, MD, a dual board-certified physician in family medicine and obesity medicine
He also suggests sticking to a consistent sleep schedule, staying active, and watching your nutrition (not just calories) to keep anxiety at bay
This separation provides theoretical safety, though the combination remains unstudied in formal clinical trials