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A later review framed the molecule honestly as a still unresolved riddle, conceding that decades of study had not pinned down a mechanism or a confirmed physiological role (PMID 16539679)
40,84 Additionally, by increasing lipid storage in adipose tissue, insulin indirectly induces leptin release from adipocytes, which strongly mediates satiety by acting on hypothalamic brain cells expressing the leptin receptor
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One study used 300 milligrams a day for four months with good tolerance
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