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JAMA Netw Open 2023;6:e2327739
In the TRIUMPH-1 trial, the 4 mg dose had a lower discontinuation rate due to adverse events than even placebo, suggesting that lower doses are well-tolerated
Without enough B12, there can be some damages in nerve function, which can lead to symptoms such as tingling and numbness
Proceed with extra caution or consider topical-only formulations
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