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To minimize the impact of nonspecific stress stimuli on the experimental animals, they should be handled for 12 min daily before the experiment

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treatment form (oral or intramuscular hydroxocobalamin) depends on the underlying cause

None of these endpoints has been validated against clinical outcomes for GLP-1R agonists specifically, and EVOKE is the cautionary case of how readily a biomarker shift and a clinical result can be conflated