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The preclinical success of chemical chaperones such as 4-PBA and TUDCA illustrates the potential of targeting ER stress and the ERAD system in metabolic diseases
Collectively, these studies provide evidence that the L-carnitine system is differentially impacted by APOE genotypes with age and following L-carnitine challenge which could later contribute to AD pathogenesis through bioenergetics deficits, FA toxicity, and cerebrovascular dysfunction in E4s, especially in females
Science 330 , 13441348 (2010)
Throughout her tenure, Cesareo has been instrumental in guiding the company through transformational change, leveraging her skills to better meet the evolving needs of a dynamic workforce
In other words, selenium helps glutathione do its thing
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