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The reaction begins when methionine synthase takes a methyl group from active folate (5-methyltetrahydrofolate) and uses methylcobalamin to transfer that methyl group to a naturally occurring amino acid called homocysteine
Malabsorption Disorders: Conditions such as pernicious anemia, Crohns disease, celiac disease, or a history of gastric bypass surgery can hinder B12 absorption
This can lead to an unusual situation where plasma B12 levels are high, but the bodys cells are actually deficient in usable B12
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