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Compounds containing -chloroacetamide moieties have been shown to bind PDI 25
PMC 12446177
4.2 Step 2 Phosphorylation by phosphoseryl-tRNA kinase The second step is the ATP-dependent phosphorylation of the serine moiety of Ser-tRNA [Ser]Sec to produce phosphoseryl-tRNA [Ser]Sec (pSer-tRNA [Ser]Sec )
Similarly, replacing the 2-chloroacetamide with a 3-chloroacetamide derivative such as in cluster-4 also proved unfavourable and resulted in loss of potency
Filali-Mouncef Y, Hunter C, Roccio F, Zagkou S, Dupont N, Primard C, et al
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