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More serious but less common adverse effects observed in trials or associated with this drug class include: Increased heart rate , a class effect seen with GLP-1 receptor agonists [15] [12] Gallbladder disease , including gallstones (cholelithiasis), which has been associated with rapid weight loss and incretin-based therapies more broadly
These findings emphasize that lipd peroxidation is not merely a byproduct of cell death but is a crucial regulatory signal that facilitates crosstalk between necroptosis and ferroptosis
Journal of lipids
The ROS-mediated activation of STAT-3/VEGF signaling is involved in the 27-hydroxycholesterol-induced angiogenesis in human breast cancer cells
Preclinical studies have shown a favorable safety profile, but more rigorous clinical trials are necessary to fully understand its potential side effects and risks
