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10.3389/fimmu.2020.626431 22 CaoJ

Published 2025 May 29

MOTS-c MOTS-c mitochondrial-derived peptide (MDP) Mitochondrial-encoded peptide studied for metabolic regulation and longevity can translocate to the nucleus under metabolic stress, regulating nuclear gene expression particularly genes involved in folate metabolism and de novo purine biosynthesis PMID: 27060479

350 Owing to the accessible crevice and the long distance between Y220 and the site at which p53 binds to DNA, Y220C is a perfect treatment target

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