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As expected 6 , PDS5B depletion led to HR deficiency that could be complemented by ectopic expression of PDS5B WT , but expression of PDS5B 17A was ineffective in this regard although the decrease in HR was less severe than that observed with knockdown of BRCA2 (Supplementary Fig

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In adults, approved indications for growth hormone therapy include childhood-onset growth hormone deficiency, adult-onset hypopituitarism (underactive pituitary gland) due to pituitary or hypothalamic disease, AIDS-related wasting syndrome, and short bowel syndrome (18, 19)