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In cardiac cells, the physical proximity between mitochondria and the sarcoplasmic reticulum (SR, a specific type of ER in heart and skeletal muscle cells) allows the exchange of Ca 2+ in local microdomains, providing rapid Ca 2+ buffering
The primary risk with GHK-Cu is sourcing quality, as unregulated peptide products may contain impurities that cause reactions attributable to contamination rather than the peptide itself
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