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These effects are well-documented with exogenous GH administration and represent the main metabolic risk of elevated growth hormone levels

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In the United States, a drug development company must file for Investigational New Drug (IND) status before a FIH trial can begin, often preceded by a pre-IND meeting with the FDA

Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing | Bentham Science Seiwerth S, et al