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However, Semaglutide is most effective when coupled with routine exercise and a healthy diet
Most of the weight back tends to come on within the first year after stopping
STEP 1 Trial - New England Journal of Medicine : The landmark clinical trial demonstrating 14.9% average weight loss with semaglutide 2.4mg over 68 weeks, establishing the efficacy and safety profile for weight management
the precise combined metabolic effects of simultaneous GLP-1, GIP, and glucagon receptor activation in humans are still being characterised
Eventually, some patients may taper off medication under medical guidance, while others continue long-term maintenance depending on individual progress
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