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Once inside the cell, metformins positive charge leads to its sequestration within the negatively charged mitochondrial matrix, where it can reach concentrations up to 1,000-fold higher than in the extracellular space (Graham et al., 2011)
10.1002/jbt.21869 156 SpinelliJ
This may help address the frustrating belly fat that can develop during menopause weight gain even when overall weight stays stable
It oxidizes rapidly in healthy individuals to benzoic acid, conjugated with glycine in the liver, and excreted as hippuric acid
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