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Following intraperitoneal administration in rat models, BPC-157 increased serotonin synthesis in the substantia nigra reticulate and medial anterior olfactory nucleus

Therefore, by activating this NCOA4-mediated ferritinophagy pathway, Erastin promotes the release of free iron, which in turn amplifies ROS production and lipid peroxidation, resulting in an autophagy-dependent mode of ferroptosis

Interestingly, we observed a 2-3 fold elevated PSPH gene and protein expression in 2012.2 cells under hypoxic conditions ( p = 0.0098 and p = 0.0082), whereas 1919 cells did not exhibit upregulation of PSPH expression (Fig

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Furthermore, the activities of GPxs and Prxs are modulated by any other antioxidants in the cells