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Weight measurements depended on routine clinical visits, adverse events may be underreported in electronic health records, and unmeasured confounding such as differences in patient motivation for weight loss may influence results

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However, there is a gap in knowledge as to understanding whether once weekly semaglutide would lead to reductions in symptoms and physical limitations and to improved exercise function, in addition to weight loss, in patients with heart failure with preserved ejection fraction and obesity

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Metabolomics profiling of blood extract obtained using NADMED extraction method was done by Ms-Omics laboratory, Denmark