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Together, these observations highlight the dual role of astrocytic autophagysupporting clearance and repair under certain conditions, yet exacerbating pathology when dysregulated
91 Although autophagosomes are often increased in MASLD, reductions in BECN1 and accumulation of p62/SQSTM1 indicate defective lysosomal degradation and impaired autophagic flux.1, 92 This dysfunction affects lipophagy, insulin signaling, inflammatory responses, and cellular stress pathways
Gagneux, S
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