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Trends Mol Med 27:673686
Thus, observed potent induction of ferroptosis, GPX4-dependent novel suppression of mTOR pathway and DNA damage repair response in preclinical in vitro model of TC supports GPX4 targeting for therapeutic benefit in advanced therapy-resistant thyroid cancers
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Meanwhile, 10 L of dosing solution of the compounds or probe substrates and 10 L of Reagent C2 (ATP) or D2 (AMP, as the non-ATP dependent control) were mixed and pre-incubated at 37C for 5 min
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