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This is notable in the light of the observation from cohort studies that the association of serum UA with PD is also stronger in males 12

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That this finding was only observed in the DLPFC (and not the ACC) in our cohort is in line with research observing frontal cortical thinning in blast exposed veterans (59), decreased activity (60), and white matter damage (61) in the PFC following mTBI

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Factors conferring relative protection to children from the toxic effect of paracetamol overdose include increases in paracetamol sulphation capacity [44,45,46,47,48], relative immaturity of the CYP450 oxidation system [15, 46, 49, 51] and the larger relative liver volume found in children [59] but these theoretical mechanisms have not been confirmed