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Researchers warn that the long-term effects of GLP-1 drugs during adolescence are not known, as no data yet exist
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371 In osteoblasts, the administration of GLP-1 and GIP incretins suppressed the excessive expression of the pro-degradative enzymes MMP-3 and MMP-13 induced by IL-1 stimulation
In addition, office-based measurements of systolic and diastolic blood pressure (BP) were reduced with tirzepatide, but heart rate (HR) was increased, consistent with known effects of GLP-1 agonists
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