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AMPK controls the inflammatory response, preserves cellular energy balance, and plays a key role in the transformation of macrophages from a proinflammatory to an anti-inflammatory phenotype during inflammation (Velagapudi et al., 2017)
The D-amino acid substitution preserves the spatial orientation of amino acid side chains needed for competitive binding to the FOXO4-p53 interaction surface, maintaining biological activity despite the non-natural backbone (PMID: 28340339)
Park, Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model, Ann
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