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A 2019 systematic review published in the National Library of Medicine identified improvements in skin brightness across several small trials while emphasising the need for larger controlled studies before definitive claims can be made

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MC1R is the receptor most relevant to pigmentation and photoprotection

After incubation for 5 days (C3G strains) or 3 days (DHQC3G strains) at 30 C, 300 rpm, 5 cm shaking diameter, 0.5 ml methanol containing 0.3% hydrochloric acid was added for extraction of flavonoids

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