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Also, salvianolic acid B pretreatment induces Nrf2 and phase II enzymes by activating phosphoinositide 3-kinase (PI3K) and protein kinase C (PKC) pathways, thereby preventing acetaminophen-induced hepatotoxicity in mice (Lin et al., 2015)
Tinggi, U
PI3K consists of four catalytic subunits (p110, , , and ) and other regulatory subunits (p101 or p85), of which and are present only in leukocytes, while the other two are widely distributed in a variety of cells
Tarkowski et al
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