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Description

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Acrolein sequestering ability of the endogenous tripeptide glycyl-histidyl-lysine (GHK): characterization of conjugation products by ESI-MSn and theoretical calculations

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BB: Funding acquisition, Project administration, Writing original draft, Supervision, Conceptualization, Writing review & editing

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Studies show that lactate increases ubiquitin-specific peptidase 39 (USP39) expression in Treg cells, a crucial part of the RNA splicing complex, leading to USP39-dependent RNA-splicing mediated cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) expression in a forkhead box P3 (foxp3)-dependent manner (63)

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