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2 hrs after reaching the maximum plasmatic concentration, the concentration of active drug is higher in the synovial fluid than in the plasma and the rest is reached in a period of 12 hrs

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F. Amicet al., Bypassing major venous occlusion and duodenal lesions in rats, and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L-arginine, Baishideng Publishing Group Inc., Dec. 2018. doi: 10.3748/wjg.v24.i47.5366

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We found that oral vitamin B12 replacement at 1000 g daily was adequate to replace vitamin B12 levels in patients with pernicious anemia