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Research in rodents indicates that apart from the activation of MMP2, the peptide might also activate fibroblasts, which produce and maintain MMP2 and other components of the extracellular matrix, such as collagen and elastin

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The hormone also decreases the parietal cells secretion of gastrin and stomach acid, proliferates the bones osteoblasts and inhibits osteoclasts, and may be involved in neuro-signaling as evidenced by widespread expression of GIPr in the brain