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GLP-1 medications (semaglutide, liraglutide) commonly cause gastrointestinal side effects including nausea, constipation, and diarrhoea by slowing gastric emptying

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It is to determine whether intake has gradually increased or whether appetite suppression is no longer adequate

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The most common TEAEs were nausea, occurring in about 70% of patients treated with HRS-7535 compared to 16.2% on placebo

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Gastrointestinal side effects such as severe constipation or gastric distension may manifest as referred pain to the back

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