Inclusion Criteria BMI 30 or greater (obesity), or BMI 27 or greater with at least one weight-related comorbidity (hypertension, type 2 diabetes, dyslipidemia, obstructive sleep apnea) History of failed lifestyle modifications (diet and exercise alone insufficient) Motivation and willingness to participate in comprehensive weight management (medication plus lifestyle changes) Ability to self-administer weekly subcutaneous injections or willingness to learn Contraindications and Precautions Semaglutide training for physicians must emphasize absolute and relative contraindications
These include age-related changes, delicate skin, genetics, and certain medications or supplements
With the emergence of the SURPASS-CVOT trial, tirzepatide (a dual GIP/GLP-1 receptor agonist) has entered the therapeutic landscape
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