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Temporal and subgroup disparities in mediation effects on cardiovascular outcomes with liraglutide and semaglutide: post-hoc analysis of LEADER and SUSTAIN-6

Average Weight Loss in the Orforglipron phase 3 ATTAIN-1 Trial Across the 72-week study period, participants: Lost up to 15% of their body weight at the highest dose At 36 mg: 54.6% lost 10%, 36.0% lost 15%, 18.4% lost 20% body weight (all higher than placebo)

The study complies with the Declaration of Helsinki

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Sample collection and DNA extraction: At the time of sacrifice, cecal contents were collected from a representative subset of four mice per group and immediately stored at -80 C until further analysis