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This is distinct from clinical depression but can feel similar and warrants monitoring by healthcare providers familiar with these medications
One clinical trial (not yet published, presented at ENDO 2024) measured ethinyl estradiol and levonorgestrel levels in women taking combination oral contraceptives with and without tirzepatide
Common side effects include: Nausea Vomiting Diarrhea Constipation Headache Fatigue Indigestion These happen because the medication slows digestion and affects appetite signals in the brain and small intestine
For instance, if your TDEE is 2,325 calories, target a daily intake of 1,825 to 2,025 calories
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