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In rodent studies, exendin-4 and dulaglutide have been detected in the brain following systemic administration, supporting their ability to engage central GLP-1 receptors, and these compounds are generally considered to be capable of penetrating the BBB (rskov et al., 1996

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Other side effects, like nausea or diarrhea, are uncommon at standard doses (500-2000 mg)

On its website, Zappy touts that its weight-loss plans "are personalized by doctors." According to Zappy's terms of service, the doctor-patient relationship isn't between Zappy and its users

This mechanistic complementarity means combining the peptides addresses more healing pathway simultaneously than either alone