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Retatrutide: Complication Focus TRIUMPH-4: Obesity + knee osteoarthritis (445 participants) TRIUMPH-2: Obesity + type 2 diabetes TRIUMPH-6: Weight maintenance trial Advantage: Multiple complication-specific trials could lead to broader label (obesity + OA + OSA indications)

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Animal studies have generally reported a favorable short-term safety profile for BPC-157, and peptides as a class tend to have fewer off-target effects than small-molecule drugs because of their specificity

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Understanding these trends helps us appreciate the ongoing research