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9 During pathological states, reaction between nitric oxide and superoxide can generate highly reactive peroxynitrite (ONOO-) radicals, which are implicated in lipid peroxidation

Persistence beyond the initial adjustment period warrants clinical review for dose modification or supportive treatment

University of Chicago Press

The other reason why it's called enough is because we have so unfairly and tragically blamed people for having a disease that is not their fault and that is not their choice