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Pickart, L., Vasquez-Soltero, J., Pickart, F., & Majnarich, J

Even in picogram quantities, they can elicit strong inflammatory and cytotoxic responses in mammalian cells, confounding experimental results

There is no clinical trial data specifically studying this approach, but some prescribers report anecdotally that patients maintain better long-term responses with periodic dose reductions

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Since SASP plays a crucial role in the cellular senescence process, its levels and precise composition can serve as valuable markers of senescence [31]