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At MC1R, MT-2 activates Gs-coupled cAMP signaling in melanocytes, promoting eumelanin synthesis through MITF and tyrosinase induction
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However, these therapeutic agents tend to have associated systemic adverse effects, including increased susceptibility to infections, hepatotoxicity, nephrotoxicity, and other complications [4, 5]
They dont need progressively higher doses to maintain effect (maintenance doses are actually lower than weight loss doses)
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