side effects of tirzepatide and semaglutide vs Effects: What's Worse? Weighing up the Risks: GI

In the only reported trial to date involving people with AUD who actively wished to reduce or cease drinking, a once-weekly GLP-1 agonist called exenatide did not result, in the overall group, in a reduction of the number of heavy drinking days, but the drug did enable those with AUD and obesity to do so

In type 2 diabetes, glutathione depletion exacerbates hyperglycemia-induced ROS production, creating a feed-forward loop in which oxidative stress both results from and worsens insulin resistance (9)

It was found that the glucagon response at 3.5 mmol/l was lower after sitagliptin than after placebo whereas at 3.1 mmol/l, glucagon did not differ between the two

Spiering BA, Kraemer WJ, Vingren JL, Hatfield DL, Fragal MS, Ho JY, Maresh CM, Anderson JM, Volek JS

(2023) NICE