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Head-to-head clinical trial data (the SURMOUNT-5 trial) shows tirzepatide (Zepbound) produces marginally better average weight loss than semaglutide (Wegovy) at equivalent treatment durations

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Side effects of weight loss medications in this class have grabbed headlines

As with any Zepbound side effects, if your stomach problems or indigestion get worse, Decotiis says to talk with your health provider and work on a solution

Fat loss often appears before significant muscle gains, which aligns with GH's more immediate effects on lipolysis versus the slower process of building new muscle tissue