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Metformin primarily reduces hepatic glucose production and improves peripheral insulin sensitivity, while tirzepatide enhances glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and promotes satiety
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12 Glucagons stimulatory effect on endogenous hepatic glucose production is a prime culprit in glucose elevations after meals
Ktk D, ner , Baar M, Akcay B, Olcay O, olak E, et al
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