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Call 911 or seek emergency medical care immediately if you experience: Signs of severe allergic reaction (anaphylaxis), including difficulty breathing, severe rash, swelling of the face or throat, or rapid heartbeat Severe, persistent abdominal pain, particularly if radiating to the back, which may indicate pancreatitis (stop taking semaglutide) Suicidal thoughts or behaviors (alternatively, call or text 988 Suicide & Crisis Lifeline) Persistent vomiting that prevents you from keeping down fluids, risking dehydration Contact your healthcare provider within 24 hours if you notice: Right upper abdominal pain, fever, or yellowing of skin/eyes, which may indicate gallbladder disease Sudden changes in vision, floaters, or vision loss, especially if you have diabetic retinopathy Severe abdominal bloating, inability to pass gas or stool, which may suggest intestinal obstruction (ileus) Signs of dehydration or possible kidney problems, including dark urine, dizziness, or decreased urination Moderate to severe nausea that interferes with eating or drinking Symptoms of hypoglycemia (particularly if taking insulin or sulfonylureas), such as shakiness, confusion, sweating, or rapid heartbeat Unexplained persistent fatigue or weakness Routine follow-up is appropriate for mild, tolerable side effects that do not interfere with daily activities