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The STEP 4 trial led by Domenica Rubino showed that the effect depends on continuation: participants switched to placebo regained roughly two-thirds of their lost weight over the following year (Rubino et al., 2021)

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Take the tablet on an empty stomach, with only a small amount of water, and wait before eating, drinking anything else or taking other oral medication

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Over-the-counter simethicone (Gas-X, Mylicon) can reduce gas bubbles in the gastrointestinal tract, though evidence for its effectiveness is limited